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Clinical studies have revealed that

daily intake of collagen peptides can

reduce joint pain and significantly improve joint comfort. 1**
  • regulate bone metabolism
  • regulate biomechanical parameters
  • develop stronger bones. 2**
collagen peptides accumulate in cartilage after digestion. 4**

10g daily collagen intake can help

  • reduce joint pain and support joint health.
  • stimulate endogenous collagen synthesis in joints.
  • Stimulate chondrocytes to produce more aggregates and collagen type 2,
  • promote healthy joints and reduce the effects of joint degeneration. 3**
Studies have shown that the use of collagen is more effective than glucosamine. 6**

the beneficial effects of collagen peptides appear to be more pronounced in individuals with severe symptoms.5**

In a study, it has been shown that the daily use of 10 g of collagen peptide helps against bone mass loss.

Collagen peptides stimulate the endogenous production of collagen in bone tissue,

trigger osteoblasts (bone formation cells) and increase bone density.7**
Research suggests that elderly individuals can benefit from supplementing their diet with protein, and especially collagen peptides can be beneficial because they are an easily absorbed protein source.8**

Collagen is largely responsible for protecting the skin by providing skin elasticity, flexibility and moisture balance.
A strong collagen structure is extremely important to prevent the formation of wrinkles.

Collagen fibers made in fibroblast cells are responsible for the maintenance and resistance of skin tissues.

Collagen peptides regulate the activity of fibroblasts in the skin and stimulate the production of collagen and hyaluronic acid, which are important for the moisture balance of the skin.9**

collagen peptides can increase the mechanical strength of the skin by increasing fibroblast density and collagen fibril formation in the subcutaneous layer.10**

Clinical studies have shown that daily use of collagen increases skin moisture levels by 28% after eight weeks, and collagen breakdown in the skin is reduced by 31% after 12 weeks of use.11**

References

1) ** Jiang JX. Et al. (2013). Peptan collagen peptides for treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled study. Agro FOOD Industry Hi Tech, Vol 25(2):19-23


2)**Guillerminet, F., Beaupied, H., Fabien-Soule, V., Tome, D., Benhamou, C-L., Blachier, F., Roux, C., and Blais, A., 2010, Collagen Peptides Improves Bone Metabolism and Biomechanical Parameters in Ovarietomized Mice: An In- Vitro and In Vivo Study, Bone

 

3)**Oesser, S. et al. (2003). Stimulation of Type II Collagen Biosynthesis and Secretion in Bovine Chondrocytes Cultured with Degraded Collagen. Cell Tissue Research,311:393-339


4**Oesser, S. et al. (1999). Oral Administration of 14 C Labelled Gelatine Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice(C57/BL). Journal of Nutrition, 129: 1891:-1895


5**Moskowits(2000) . Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30(2):87-99.


6**Trc T et al. (2011). Efficacy and tolerance of enzymatic hydrolysed collagen(EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). International Orthopaedics, 35(3):341-348.


7**Wu, J., Fujioka, M., Sugimoto, K., Mu, Gi, and Ishimi, Y., 2004, Assessment of Effectiveness of Oral Administration of Collagen Peptide on Bone Metabolism in Growing and Mature Rats, Journal of Bone and Mineral Metabolism, 22: 547-553; Mizuno, M. And Kuboki, Y., 2001, Osteoblast-Related Gene Expression of Bone Marrow Cells During the Osteoblast Differentiation Induced by Type I Collagen, Journal of Biochemistry, 129:133-138


8**Hays et al, 2009, Effects of Whey and Fortified Collagen Hydrolysate Protein Supplements on Nitrogen Balance and Body Composition in Older Women, Journal of the American Dietetic Association


9**(Ohara, H. Et al., 2010, Collagen-derived Dipeptide, Proline-hydroxyroline Stimulates Cell Proliferation and Hyaluronic Aid Syntesis in Cultured Human Dermal Fibroblasts, Journal of Dermatology, 37: 330-338)


10**(Matsuda, N., Koyama, Y., Hosaka, Y., Ueda, H., Watanabe, T., Araya, T., Irie, S. and Takehana, K. 2006, Effects of Ingestion of Collagen Peptide on Collagen fibrils and Glycosaminoglycans in the Dermis, Journal of Nutritional Science and Vitaminology, 52:211-215)


11** (Asserin J, Lati E, Shioya T and Prawitt J, 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14:291-301. Doi:10.1111/jocd.12174)

According to National Osteoporosis Foundation Data:

It has been reported that approximately 20% (approximately 57 million)
of individuals in the USA develop joint degeneration or bone mass loss.
In another worldwide study conducted in 2007, it was determined that approximately 30% of individuals
aged 60 years and older experienced muscle loss.

This highlights the importance of healthy aging.
The new topic in healthcare is prevention rather
than treatment. This also Increases the popularity
of supplements as they are used for

Collagen is largely responsible for protecting the skin by providing skin elasticity, flexibility and moisture balance.
A strong collagen structure is extremely important to prevent the formation of wrinkles.
Collagen fibers made in fibroblast cells are responsible for the maintenance and resistance of skin tissues.

Collagen peptides regulate the activity of fibroblasts in the skin and stimulate the production of collagen and hyaluronic acid, which are important for the moisture balance of the skin.

(Ohara, H. Et al., 2010, Collagen-derived Dipeptide, Proline-hydroxyroline Stimulates Cell Proliferation and Hyaluronic Aid Syntesis in Cultured Human Dermal Fibroblasts, Journal of Dermatology, 37: 330-338)
 

Studies have shown that collagen peptides can increase the mechanical strength of the skin by increasing fibroblast density and collagen fibril formation in the subcutaneous layer.

(Matsuda, N., Koyama, Y., Hosaka, Y., Ueda,  H., Watanabe, T., Araya, T., Irie, S. and Takehana, K. 2006, Effects of Ingestion of Collagen Peptide on Collagen fibrils and Glycosaminoglycans in the Dermis, Journal of Nutritional Science and Vitaminology, 52:211-215)
 

Clinical studies have shown that daily use of collagen increases skin moisture levels by 28% after eight weeks, and collagen breakdown in the skin is reduced by 31% after 12 weeks of use.

(Asserin J, Lati E, Shioya T and Prawitt J, 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14:291-301. Doi:10.1111/jocd.12174)
 

Clinical studies have shown that daily use of collagen increases skin moisture levels by 28% after eight weeks, and collagen breakdown in the skin is reduced by 31% after 12 weeks of use.

(Asserin J, Lati E, Shioya T and Prawitt J, 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14:291-301. Doi:10.1111/jocd.12174)